Key Research Articles

ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.

Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L., Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ.

Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2023157118. 

Linking ubiquitin to actin dynamics during cell fusion.

Lignitto L., Pagano M.

Dev Cell. 2021 Mar 8;56(5):569-570. 

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1.

Lignitto L., LeBoeuf S.E., Homer H., Jiang S., Askenazi M., Karakousi T.R., Pass H.I., Bhutkar A.J., Tsirigos A., Ueberheide B., Sayin V.I., Papagiannakopoulos T., and Pagano M. 

Cell. 2019 Jul 11;178(2):316-329.e18. (See also related Preview, N&V, F1000, and In the News)

Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway.

Sepe M., Lignitto L., Porpora M., Delle Donne R., Rinaldi L., Belgianni G., Colucci G., Cuomo O., Viggiano D., Scorziello A., Garbi C., Annunziato L., Feliciello A. 

Proc Natl Acad Sci USA. 2014 Nov 4;111(44):15729-34.

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates the Hippo pathway and supports glioblastoma growth.

Lignitto L., Arcella A., Sepe M., Rinaldi L., Delle Donne R., Gallo A., Stefan E., A. Bachmann V., Oliva MA., Storlazzi CT, L’Abbate A., Brunetti A., Gargiulo S., Gramanzini M., Insabato L., Garbi C., Gottesman M.E., and Feliciello A. 

Nature Commun. 2013;4:1822.

Expression of the Ring Ligase PRAJA2 in Thyroid Cancer.

Cantara S., D'Angeli F., Toti P., Lignitto L., Castagna MG., Capuano S., Prabhakar BS., Feliciello A., Pacini F. 

J Clin Endocrinol Metab. 2012 Nov;97(11):4253-9. 

An intimate connection between ubiquitination and compartmentalized cAMP signaling.

Lignitto L., Sepe M., Carlucci A., and Feliciello A. 

Cell Cycle. 2011 Jul 1;10(13):2051-2. 

Control of PKA stability and signalling by RING ligase Praja2.

Lignitto L., Carlucci A., Sepe M., Stefan E., Cuomo O., Nisticò R., Scorziello A., Savoia C., Garbi C., Annunziato L., and Feliciello A. 

Nature Cell Biol. 2011 Apr;13(4):412-22. (See also related N&V)

Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome.

Carlucci A., Lignitto L., Feliciello A. 

Trends Cell Biol. 2008 Dec;18(12):604-13. 

Protein tyrosine phosphatase PTPD1 regulates FAK autophosphorylation and cell migration.

Carlucci A., Gedressi C., Lignitto L., Avvedimento V.E., Villa-Moruzzi E., Nezi L., Garbi C., and Feliciello A. 

J Biol Chem. 2008 Apr 18;283(16):10919-29.