The Calanques

UNCOVERING THE MECHANISMS BEHIND TUMOR EVOLUTION

Our laboratory seeks to achieve a deep understanding of how the heme-oxidative stress pathway regulates protein degradation, via the ubiquitin-proteasome system, and gene expression, via modulation of transcriptional sensors. We exploit our mechanistic studies to uncover how genetic and environmental alterations of this pathway rewire cancer cells signaling and impact on lung tumor evolution. Our long-term goal is to identify new strategies and tools to develop precision therapeutics for lung cancer patients. In this effort, our laboratory bridges knowledge of basic and translational science.

In the heart of Marseille, the Calanque National Park