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Luca Lignitto, PhD
Group Leader
Career summary
Throughout my career, I have been interested in the molecular mechanisms underlying the degradation of proteins controlled by the Ubiquitin-Proteasome System (UPS). For the last 14 years, I specialized in the study of E3 ubiquitin ligases, identifying their proteolytic substrates and defining the pathophysiological relevance of their degradation. For my investigations I acquired extensive expertise in a wide range of experimental methods of molecular biology, biochemistry, proteomics, genomics, and mouse models. During my PhD training in the lab of Dr. Antonio Feliciello at the University of Naples “Federico II” in Italy, I dissected the molecular machinery mediating the cross-regulation between the cyclic AMP signaling pathway and the UPS (Lignitto et al., Nature Cell Biol., 2011). As a postdoc, first, in my graduate student lab, and afterwards at New York University (NYU) in the USA, I focused my studies on the UPS-regulated signaling networks underpinning oncogenesis (Lignitto et al., Nature Commun., 2013) (Lignitto et al., Cell, 2019). In particular, during my postdoc in the lab of Dr. Michele Pagano at NYU, I uncovered the existence of a molecular network that links mutations of the oxidative stress pathway to alterations of the heme signaling and UPS-mediated protein degradation, which ultimately promotes oncogenesis. Currently, I am a Group Leader at the Marseille Cancer Research Centre (CRCM) and at the Centre national de la recherche scientifique (CNRS) in Marseille. My laboratory focuses on understanding how heme signaling and oxidative stress regulate cellular physiology and cancer pathogenesis. Our long-term goal is to identify new therapeutic approaches for cancer patients harboring alterations of the heme-oxidative stress pathway.
Luca Lignitto, PhD
Group Leader
Career summary
Throughout my career, I have been interested in the molecular mechanisms underlying the degradation of proteins controlled by the Ubiquitin-Proteasome System (UPS). For the last 14 years, I specialized in the study of E3 ubiquitin ligases, identifying their proteolytic substrates and defining the pathophysiological relevance of their degradation. For my investigations I acquired extensive expertise in a wide range of experimental methods of molecular biology, biochemistry, proteomics, genomics, and mouse models. During my PhD training in the lab of Dr. Antonio Feliciello at the University of Naples “Federico II” in Italy, I dissected the molecular machinery mediating the cross-regulation between the cyclic AMP signaling pathway and the UPS (Lignitto et al., Nature Cell Biol., 2011). As a postdoc, first, in my graduate student lab, and afterwards at New York University (NYU) in the USA, I focused my studies on the UPS-regulated signaling networks underpinning oncogenesis (Lignitto et al., Nature Commun., 2013) (Lignitto et al., Cell, 2019). In particular, during my postdoc in the lab of Dr. Michele Pagano at NYU, I uncovered the existence of a molecular network that links mutations of the oxidative stress pathway to alterations of the heme signaling and UPS-mediated protein degradation, which ultimately promotes oncogenesis. Currently, I am a Group Leader at the Marseille Cancer Research Centre (CRCM) and at the Centre national de la recherche scientifique (CNRS) in Marseille. My laboratory focuses on understanding how heme signaling and oxidative stress regulate cellular physiology and cancer pathogenesis. Our long-term goal is to identify new therapeutic approaches for cancer patients harboring alterations of the heme-oxidative stress pathway.
Luca Lignitto, PhD
Group Leader
Career summary
Throughout my career, I have been interested in the molecular mechanisms underlying the degradation of proteins controlled by the Ubiquitin-Proteasome System (UPS). For the last 14 years, I specialized in the study of E3 ubiquitin ligases, identifying their proteolytic substrates and defining the pathophysiological relevance of their degradation. For my investigations I acquired extensive expertise in a wide range of experimental methods of molecular biology, biochemistry, proteomics, genomics, and mouse models. During my PhD training in the lab of Dr. Antonio Feliciello at the University of Naples “Federico II” in Italy, I dissected the molecular machinery mediating the cross-regulation between the cyclic AMP signaling pathway and the UPS (Lignitto et al., Nature Cell Biol., 2011). As a postdoc, first, in my graduate student lab, and afterwards at New York University (NYU) in the USA, I focused my studies on the UPS-regulated signaling networks underpinning oncogenesis (Lignitto et al., Nature Commun., 2013) (Lignitto et al., Cell, 2019). In particular, during my postdoc in the lab of Dr. Michele Pagano at NYU, I uncovered the existence of a molecular network that links mutations of the oxidative stress pathway to alterations of the heme signaling and UPS-mediated protein degradation, which ultimately promotes oncogenesis. Currently, I am a Group Leader at the Marseille Cancer Research Centre (CRCM) and at the Centre national de la recherche scientifique (CNRS) in Marseille. My laboratory focuses on understanding how heme signaling and oxidative stress regulate cellular physiology and cancer pathogenesis. Our long-term goal is to identify new therapeutic approaches for cancer patients harboring alterations of the heme-oxidative stress pathway.
Luca Lignitto, PhD
Group Leader
Career summary
Throughout my career, I have been interested in the molecular mechanisms underlying the degradation of proteins controlled by the Ubiquitin-Proteasome System (UPS). For the last 14 years, I specialized in the study of E3 ubiquitin ligases, identifying their proteolytic substrates and defining the pathophysiological relevance of their degradation. For my investigations I acquired extensive expertise in a wide range of experimental methods of molecular biology, biochemistry, proteomics, genomics, and mouse models. During my PhD training in the lab of Dr. Antonio Feliciello at the University of Naples “Federico II” in Italy, I dissected the molecular machinery mediating the cross-regulation between the cyclic AMP signaling pathway and the UPS (Lignitto et al., Nature Cell Biol., 2011). As a postdoc, first, in my graduate student lab, and afterwards at New York University (NYU) in the USA, I focused my studies on the UPS-regulated signaling networks underpinning oncogenesis (Lignitto et al., Nature Commun., 2013) (Lignitto et al., Cell, 2019). In particular, during my postdoc in the lab of Dr. Michele Pagano at NYU, I uncovered the existence of a molecular network that links mutations of the oxidative stress pathway to alterations of the heme signaling and UPS-mediated protein degradation, which ultimately promotes oncogenesis. Currently, I am a Group Leader at the Marseille Cancer Research Centre (CRCM) and at the Centre national de la recherche scientifique (CNRS) in Marseille. My laboratory focuses on understanding how heme signaling and oxidative stress regulate cellular physiology and cancer pathogenesis. Our long-term goal is to identify new therapeutic approaches for cancer patients harboring alterations of the heme-oxidative stress pathway.
Luca Lignitto, PhD
Group Leader
Career summary
Throughout my career, I have been interested in the molecular mechanisms underlying the degradation of proteins controlled by the Ubiquitin-Proteasome System (UPS). For the last 14 years, I specialized in the study of E3 ubiquitin ligases, identifying their proteolytic substrates and defining the pathophysiological relevance of their degradation. For my investigations I acquired extensive expertise in a wide range of experimental methods of molecular biology, biochemistry, proteomics, genomics, and mouse models. During my PhD training in the lab of Dr. Antonio Feliciello at the University of Naples “Federico II” in Italy, I dissected the molecular machinery mediating the cross-regulation between the cyclic AMP signaling pathway and the UPS (Lignitto et al., Nature Cell Biol., 2011). As a postdoc, first, in my graduate student lab, and afterwards at New York University (NYU) in the USA, I focused my studies on the UPS-regulated signaling networks underpinning oncogenesis (Lignitto et al., Nature Commun., 2013) (Lignitto et al., Cell, 2019). In particular, during my postdoc in the lab of Dr. Michele Pagano at NYU, I uncovered the existence of a molecular network that links mutations of the oxidative stress pathway to alterations of the heme signaling and UPS-mediated protein degradation, which ultimately promotes oncogenesis. Currently, I am a Group Leader at the Marseille Cancer Research Centre (CRCM) and at the Centre national de la recherche scientifique (CNRS) in Marseille. My laboratory focuses on understanding how heme signaling and oxidative stress regulate cellular physiology and cancer pathogenesis. Our long-term goal is to identify new therapeutic approaches for cancer patients harboring alterations of the heme-oxidative stress pathway.
Uncovering the mechanisms behind tumor evolution
In the heart of Marseille..
the Calanques national park
...our laboratory seeks to achieve a deep understanding of how the heme-oxidative stress pathway regulates protein degradation, via the ubiquitin-proteasome system, and gene expression, via modulation of transcriptional sensors. We exploit our mechanistic studies to uncover how genetic and environmental alterations of this pathway rewire cancer cells signaling and impact on lung tumor evolution. Our long-term goal is to identify new strategies and tools to develop precision therapeutics for lung cancer patients. In this effort, our laboratory bridges knowledge of basic and translational science...
We strongly support diversity and inclusion; we welcome scientists from all over the world, and we are particularly keen to host young, passionate investigators eager to perform ground-breaking research, explore new scientific fields and master new technology
العلم فوضى كيما الكوزينة، خلط و جلط حتى تتنظم... Algerian
I think that science is very much like cooking.. "mix and blend until you make it!"... English
Tá taighde eolaíoch cosúil le fanacht ar bhus i bhfásach, agus ansin teacht ar bhád... Gaelic
Research is like waiting for a bus in a desert, and then a boat arrives... English
研究就好像一盒柏蒂全味豆，你永遠不知道會拿到什麼... Mandarin
Research is like a box of Bertie Bott, you never know what you're going to get... English
جو واحد اچھا کینسر سیل ہے .. یہ ایک مردہ کینسر سیل ہے... Urdu
یوازې یو سرطان سیل ښه ده. چې مړ دی... Pachtoune
The only good cancer cell.. it is a dead cancer cell... English
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Le médecin m’a dit que j’avais une assez mauvaise dépendance à la science.. Je dois me détendre... French
The doctor told me I have a pretty bad addiction to science.. I should take it easy... English
La scienza è come la pizza.. c’è un gusto per tutti.. solo non metteteci sopra l’ananas... Italian
A’ scienz’ è comm’ á pizz’.. ce stá nu gust pé tutt’ quant’.. sul nun ce mettit’ l’ananas ńgopp’... Neapolitan
Science is like a pizza.. there is a flavor for everybody.. just don’t put pineapple on it... English
Our laboratory is located in the Cancer Research Center of Marseille (CRCM). The mission of our institute is to push forward the development of new anti-cancer therapies by working at the forefront of different disciplines interfacing basic, translational, and clinical research. CRCM offers a broad, state-of-the-art technological portfolio, as well as an excellent environment to foster dynamic interactions among students, outstanding junior faculty and distinguished senior members. CRCM is located in the south-east of Marseille, a vibrant, up-and-coming city in the south region of France. Marseille, the second largest city in France and one of the main ports in Europe, offers a thriving, international environment gathering people from many different countries
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